Most studies have not found an increased chance for birth defects when pseudoephedrine is used during the first trimester. In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. There are no studies looking at whether pseudoephedrine would increase the chance of miscarriage.ĭoes taking pseudoephedrine in the first trimester increase the chance of birth defects? It is important to consider the benefits of treating nasal congestion, allergies, colds, and other respiratory infections during pregnancy.ĭoes taking pseudoephedrine increase the chance of miscarriage? If taking pseudoephedrine was recommended by your healthcare provider, talk with them before making any changes in this medication. There are no studies looking at whether pseudoephedrine could make it harder to get pregnant. Can it make it more difficult for me to become pregnant? In many places, products containing pseudoephedrine are only available upon request behind the pharmacy counter. Pseudoephedrine can be combined with other ingredients to help treat symptoms that may come with having a cold or allergies. Pseudoephedrine is sold under many different brand names. Pseudoephedrine is a decongestant that is used to treat nasal congestion (“stuffy nose”) caused by colds or allergies. This information should not take the place of medical care and advice from your healthcare provider. This sheet talks about exposure to pseudoephedrine in a pregnancy and while breastfeeding.